BPPS: An Algorithm for Analyzing Protein Sequence Alignments
نویسنده
چکیده
selection (BPPS), which is based on a two-way mixture model and can simultaneously classify protein sequences into distinct subfamilies and select conserved positions that are characteristic of these subfamilies. When applied to P-loop GTPases, this revealed within Rab, Rho, Ras, and Ran a canonical network of molecular interactions centered on bound nucleotide. This network presumably performs a crucial structural and/or mechanistic role considering that it has persisted for more than a billion years after the divergence of these families. Abstract
منابع مشابه
A word-oriented approach to alignment validation
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تاریخ انتشار 2003